Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMIFDPL)

Drug Name
AS-8112 Drug Info
Indication
Disease Entry ICD 11 Status REF
Vomiting MD90 Terminated [1]
Cross-matching ID
PubChem CID
10363531
TTD Drug ID
DMIFDPL

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 3A receptor (HTR3A) TTPC4TU 5HT3A_HUMAN Antagonist [2]
Dopamine D3 receptor (D3R) TT4C8EA DRD3_HUMAN Antagonist [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
5-HT 3A receptor (HTR3A) DTT HTR3A 5.693 5.728 5.986 6.087
Dopamine D3 receptor (D3R) DTT DRD3 1.379 2.446 1.233 1.07
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Vomiting
ICD Disease Classification MD90
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Dopamine D3 receptor (D3R) DTT DRD3 2.84E-03 0.13 2
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009088)
2 Emerging drugs for chemotherapy-induced emesis. Expert Opin Emerg Drugs. 2006 Mar;11(1):137-51.