Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMIMD0T)

Drug Name

ARI-3099 Drug Info

Synonyms

compound 6 [PMID: 23594271]; compound 226 [PMID: 24997602]; Py(D)AlaboroPro

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acylamino-acid-releasing enzyme (APEH)	TTYWEDQ	ACPH_HUMAN	Inhibitor	[1]
Prolyl endopeptidase FAP (FAP)	TTGPQ0F	SEPR_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Prolyl endopeptidase FAP (FAP)	DTT	FAP	2.585	3.689	3.018	3.202

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Prolyl endopeptidase FAP (FAP)	DTT	FAP	2.01E-01	0.07	0.84

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity. Nat Chem Biol. 2014 Aug;10(8):656-63.
2	Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase. J Med Chem. 2013 May 9;56(9):3467-77.