Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMIQ31Y)

Drug Name
Custirsen Drug Info
Synonyms OGX-001/TV-1011; OGX-011
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 3 [1]
Lung cancer 2C25.0 Phase 3 [1]
Prostate cancer 2C82.0 Phase 3 [1]
Cross-matching ID
PubChem CID
72941942
CAS Number
CAS 890056-27-6
TTD Drug ID
DMIQ31Y

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Clusterin messenger RNA (Clusterin mRNA) TTRL76H CLUS_HUMAN Not Available [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Clusterin messenger RNA (Clusterin mRNA) DTT CLU 11.116 7.204 9.644 7.223
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 02 Neoplasm
Disease Class ICD-11: 2C82 Prostate cancer
The Studied Tissue Prostate
The Studied Disease Prostate cancer [ICD-11:2C82]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Clusterin messenger RNA (Clusterin mRNA) DTT CLU 1.52E-04 -0.66 -0.65
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016680)
2 Over-expression of clusterin is a resistance factor to the anti-cancer effect of histone deacetylase inhibitors. Eur J Cancer. 2009 Jul;45(10):1846-54.