Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMIRPSA)

Drug Name
Mitoglitazone Drug Info
Synonyms MSDC-0160; Mitoglitazone (TN)
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Phase 2 [1] , [2]
Type-2 diabetes 5A11 Phase 2 [3]
Cross-matching ID
PubChem CID
10429242
ChEBI ID
CHEBI:94409
CAS Number
CAS 146062-49-9
TTD Drug ID
DMIRPSA

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Insulin receptor (INSR) TTCBFJO INSR_HUMAN Modulator [4]
Mitochondrial protein unspecific (MP) TTSJH2W NOUNIPROTAC Modulator [1] , [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Insulin receptor (INSR) DTT INSR 5.213 5.838 5.779 5.591
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Alzheimer disease
ICD Disease Classification 8A20
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Insulin receptor (INSR) DTT INSR 1.03E-05 0.26 0.66
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 ClinicalTrials.gov (NCT01103414) Study to Evaluate the Safety, Tolerability and Efficacy of Three Dose Levels of Mitoglitazone in Type 2 Diabetic Patients. U.S. National Institutes of Health.
4 An evaluation of MSDC-0160, a prototype mTOT modulating insulin sensitizer, in patients with mild Alzheimer's disease. Curr Alzheimer Res. 2014;11(6):564-73.