Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMIY79U)

Drug Name

GNF-PF-3832 Drug Info

Synonyms

3-(4-methylphenyl)-5H-indeno[1,2-c]pyridazin-5-one; GNF-PF-3832; 300843-87-2; AC1MCE1I; Cambridge id 5215436; Oprea1_419211; CBDivE_007454; MLS000104226; CHEMBL261693; cid_2767330; KS-00001RTF; BDBM21629; MolPort-002-136-671; HMS1578F11; HMS2748H23; ZINC196662; STK746982; MMV666021; AKOS001704735; MCULE-6620780852; SMR000051275; SR-01000507948; 3-(4-methylphenyl)indeno[1,2-c]pyridazin-5-one; 11K-012; SR-01000507948-1

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2767330
CAS Number: CAS 300843-87-2
TTD Drug ID: DMIY79U

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Angiotensin II receptor type-1 (AGTR1)	TT8DBY3	AGTR1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Angiotensin II receptor type-1 (AGTR1)	DTT	AGTR1	9.315	6.241	6.761	5.625

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Angiotensin II receptor type-1 (AGTR1)	DTT	AGTR1	8.95E-01	1.34E-02	0.07

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.