Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMJ14NE)

Drug Name

WAY-207024 Drug Info

Synonyms

WAY-207024; CHEMBL474991; 872002-72-7; GTPL5582; SCHEMBL3275225; SCHEMBL13324654; BDBM50256882; ZINC35923465; WAY 207024; NCGC00370941-01; KB-81482; 6-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-4-yl)piperazin-1-yl)methyl)quinoxaline

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11496610
TTD Drug ID: DMJ14NE

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Gonadotropin-releasing hormone receptor (GNRHR)	TT8R70G	GNRHR_HUMAN	Inhibitor	[2]
Histamine H2 receptor (H2R)	TTQHJ1K	HRH2_HUMAN	Inhibitor	[3]
Substance-K receptor (TACR2)	TTYO0A3	NK2R_HUMAN	Inhibitor	[3]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Substance-K receptor (TACR2)	DTT	TACR2	2.807	7.373	5.433	6.018
Histamine H2 receptor (H2R)	DTT	HRH2	5.087	5.121	4.661	4.609
Gonadotropin-releasing hormone receptor (GNRHR)	DTT	GNRHR	4.372	3.926	1.433	0.926

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Substance-K receptor (TACR2)	DTT	TACR2	6.83E-01	-2.22E-03	-0.01

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5582).
2	Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2512-5.
3	Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the ... J Med Chem. 2009 Apr 9;52(7):2148-52.