Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMJ14OV)

Drug Name
R-116712 Drug Info
Indication
Disease Entry ICD 11 Status REF
Pain MG30-MG3Z Investigative [1]
Cross-matching ID
TTD Drug ID
DMJ14OV

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 4 receptor (HTR4) TT07C3Y 5HT4R_HUMAN Antagonist [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
5-HT 4 receptor (HTR4) DTT HTR4 5.776 4.945 5.062 4.828
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Pain
ICD Disease Classification MG30-MG3Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
5-HT 4 receptor (HTR4) DTT HTR4 6.16E-01 -0.03 -0.24
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Mapping of serotonin 5-HT(4) receptor mRNA and ligand binding sites in the post-mortem human brain. Synapse. 2000 Apr;36(1):35-46.