Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMJ47QC)

• Drug Name: Thyrotropin Drug Info
• Synonyms: Thytropar

Indication

Disease Entry	ICD 11	Status	REF
Hypothyroidism	5A00	Approved	[1]

• Cross-matching ID: TTD Drug ID: DMJ47QC

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thyrotropin receptor (TSHR)	TT6NYJA	TSHR_HUMAN	Modulator	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Thyrotropin receptor (TSHR)	DTT	TSHR	2.036	2.406	0.848	2.585

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Hypothyroidism
• ICD Disease Classification: 5A00

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Thyrotropin receptor (TSHR)	DTT	TSHR	9.30E-18	-0.72	-1

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.