Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMJ4SDM)

Drug Name
3-chlorotyrosine Drug Info
Synonyms
Monochlorotyrosine; Tyrosine, 3-chloro-; 3-Chloro-DL-tyrosine; C9H10ClNO3; 2-amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid; 7298-90-0; AC1L3OFH; AC1Q3M6L; SCHEMBL157442; L-(8CI)-3-chloro-Tyrosine; GTPL5114; CTK7I4440; ACWBBAGYTKWBCD-UHFFFAOYSA-N; AKOS009158821; VZ26714; MCULE-5698335509; KB-31251; LS-177012; A838069; 2-azanyl-3-(3-chloranyl-4-oxidanyl-phenyl)propanoic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
110992
ChEBI ID
CHEBI:53678
CAS Number
CAS 7423-93-0
TTD Drug ID
DMJ4SDM

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tyrosine 3-monooxygenase (TH) TTUHP71 TY3H_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Tyrosine 3-monooxygenase (TH) DTT TH 2.322 2.233 2.036 2.07
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tyrosine 3-monooxygenase (TH) DTT TH 9.10E-04 -2.73 -1.55
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5114).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1243).