Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMJN8XK)

Drug Name

[2-(Pyrazol-1-yl)ethyl]-bisphosphonic acid Drug Info

Synonyms

CHEMBL457069; 2-(pyrazol-1-yl)ethane-1,1-diphosphonic acid; [2-(Pyrazol-1-yl)ethyl]-bisphosphonic acid; SCHEMBL10410288; UUGUSMHQBIUYKQ-UHFFFAOYSA-N; BDBM50273715

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 23043575
TTD Drug ID: DMJN8XK

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Geranyltranstransferase (FDPS)	TTIKWV4	FPPS_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Geranyltranstransferase (FDPS)	DTT	FDPS	7.06E-03	-0.73	-2.57

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocy... J Med Chem. 2008 Nov 13;51(21):6800-7.