Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMJPXZ4)

Drug Name

GSK618334 Drug Info

Synonyms

Fingolimod hydrochloride; 162359-56-0; FTY720; Fingolimod HCl; Gilenya; Gilenia; Fty-720; Fty 720; Fingolimod (FTY720) HCl; Fingolimod (hydrochloride); 2-Amino-2-(4-octylphenethyl)propane-1,3-diol hydrochloride; 2-Amino-2-(2-(4-octylphenyl)ethyl)-1,3-propanediol hydrochloride; UNII-G926EC510T; Fingolimod hydrochloride [USAN]; CHEBI:63112; G926EC510T; 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride; AK-33554; 2-AMINO-2-[2-(4-OCTYL-PHENYL)-ETHYL]-PROPANE-1,3-DIOL HCL; Fingolimod-d4 Hydrochloride

Indication

Disease Entry	ICD 11	Status	REF
Drug abuse	6C4G.1Z	Phase 1	[1]
Nasopharyngeal carcinoma	2B6B	Investigative	[2]

Cross-matching ID

PubChem CID: 107969
ChEBI ID: CHEBI:63112
CAS Number: CAS 162359-56-0
TTD Drug ID: DMJPXZ4
INTEDE Drug ID: DR0697

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D3 receptor (D3R)	TT4C8EA	DRD3_HUMAN	Antagonist	[3]
Sphingosine kinase 1 (SPHK1)	TTOHFIY	SPHK1_HUMAN	Inhibitor	[2]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	Highest Status	REF
Cytochrome P450 4F2 (CYP4F2)	DE3GT9C	CP4F2_HUMAN	Approved	[4]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Sphingosine kinase 1 (SPHK1)	DTT	SPHK1	6.441	6.18	5.508	5.845
Dopamine D3 receptor (D3R)	DTT	DRD3	1.379	2.446	1.233	1.07
Cytochrome P450 4F2 (CYP4F2)	DME	CYP4F2	9.269	3.446	3.655	8.828

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Drug abuse

ICD Disease Classification

6C4G.1Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dopamine D3 receptor (D3R)	DTT	DRD3	2.84E-03	0.13	2
Cytochrome P450 4F2 (CYP4F2)	DME	CYP4F2	5.10E-01	-3.24E-02	-1.39E-01

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	ClinicalTrials.gov (NCT00513279) To Investigate If Single Doses Of GSK618334 Are Safe And To Investigate Blood Levels Of GSK618334. U.S. National Institutes of Health.
2	Sphingosine kinase 1 is a potential therapeutic target for nasopharyngeal carcinoma.Oncotarget. 2016 Dec 6;7(49):80586-80598.
3	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
4	Product information - Gilenya.