Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMJS9YB)

Drug Name

FR-62765 Drug Info

Synonyms

FR-62765; 105346-34-7; FR 62765; ODHJHYPKZNTPCS-UHFFFAOYSA-N; AC1L2TN6; SCHEMBL5953715; Ethyl 2,5-dihydro-4-methoxy-5-oxo-3-phenyl-2-furanpropanoate; ethyl 3-(4-methoxy-5-oxo-3-phenyl-2H-furan-2-yl)propanoate; ethyl 3-(4-methoxy-5-oxo-3-phenyl-2,5-dihydro-2-furyl)propionate; 2-Furanpropanoic acid, 2,5-dihydro-4-methoxy-5-oxo-3-phenyl-, ethyl ester

Indication

Disease Entry	ICD 11	Status	REF
Diabetic complication	5A2Y	Terminated	[1]

Cross-matching ID

PubChem CID: 128354
CAS Number: CAS 105346-34-7
TTD Drug ID: DMJS9YB

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aldose reductase (AKR1B1)	TTFBNVI	ALDR_HUMAN	Modulator	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Aldose reductase (AKR1B1)	DTT	AKR1B1	7.436	8.652	9.874	8.066

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Diabetic complication

ICD Disease Classification

5A2Y

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Aldose reductase (AKR1B1)	DTT	AKR1B1	1.08E-20	0.94	1.58

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Studies on WF-3681, a novel aldose reductase inhibitor. IV. Effect of FR-62765, a derivative of WF-3681, on the diabetic neuropathy in rats. J Antibiot (Tokyo). 1991 Apr;44(4):441-4.