Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMJY1KR)

Drug Name

BNP-FIX Drug Info

Synonyms

Gene therapy (BNP, hemophilia B); Biological Nano Particles-Factor IX (hemophilia B), Asklepios; Gene therapy (BNP, hemophilia B), Asklepios; Gene therapy (hemophilia B), Asklepios/Bayer

Indication

Disease Entry	ICD 11	Status	REF
Factor IX deficiency	3B11	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMJY1KR

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Coagulation factor IX (F9)	TTFEZ5Q	FA9_HUMAN	Modulator	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Coagulation factor IX (F9)	DTT	F9	11.652	4.365	4.591	4.667

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Factor IX deficiency

ICD Disease Classification

3B11

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Coagulation factor IX (F9)	DTT	F9	5.69E-01	-0.13	-0.45

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2364).