Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMK230A)

Drug Name

CS-3030 Drug Info

Synonyms

R-142086; Factor Xa inhibitor (DVT/ pulmonary embolism), Daiichi Sankyo; Factor Xa inhibitor (DVT/ pulmonary embolism), Sankyo; Factor Xa inhibitor (deep vein thrombosis/ pulmonary embolism), Daiichi Sankyo; Factor Xa inhibitor (deep vein thrombosis/ pulmonary embolism), Sankyo

Indication

Disease Entry	ICD 11	Status	REF
Thrombosis	DB61-GB90	Preclinical	[1]

Cross-matching ID

TTD Drug ID: DMK230A

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Coagulation factor Xa (F10)	TTCIHJA	FA10_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Coagulation factor Xa (F10)	DTT	F10	7.763	4.672	3.248	4.609

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Thrombosis

ICD Disease Classification

DB61-GB90

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Coagulation factor Xa (F10)	DTT	F10	4.84E-02	-0.28	-0.9

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022617)
2	Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7.