Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMK2PBD)

Drug Name
Palonosetron + fosnetupitant Drug Info
Indication
Disease Entry ICD 11 Status REF
Chemotherapy-induced nausea MD90 Approved [1]
Cross-matching ID
TTD Drug ID
DMK2PBD

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 3A receptor (HTR3A) TTPC4TU 5HT3A_HUMAN Antagonist [1]
Substance-P receptor (TACR1) TTZPO1L NK1R_HUMAN Antagonist [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Substance-P receptor (TACR1) DTT TACR1 3.597 4.186 4.271 5.113
5-HT 3A receptor (HTR3A) DTT HTR3A 5.693 5.728 5.986 6.087
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Chemotherapy-induced nausea
ICD Disease Classification MD90
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Substance-P receptor (TACR1) DTT TACR1 7.40E-01 0.02 0.07
Substance-P receptor (TACR1) DTT TACR1 8.57E-01 -0.02 -0.18
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.