Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMK3TEV)

Drug Name

5-(trifluoromethoxy)-1H-indole-2,3-dione Drug Info

Synonyms

5-(Trifluoromethoxy)isatin; 169037-23-4; 5-(TRIFLUOROMETHOXY)INDOLINE-2,3-DIONE; 5-(trifluoromethoxy)-1H-indole-2,3-dione; 5-trifluoromethoxyisatin; 5-Trifluoromethoxy-1H-indole-2,3-dione; 1H-Indole-2,3-dione, 5-(trifluoromethoxy)-; MFCD00192524; 5-(Trifluoromethoxy)-2,3-indolinedione; AK-33632; 5-(Trifluoromethoxy)isatin, 97%; AC1MBXBJ; 5-trifluoromethoxy isatin; buttpark 34\07-90; ACMC-209dz9; Isatin-based compound, 36; 5-(trifluoromethoxy)-isatin; KSC498C3D; SCHEMBL457929; CHEMBL116649; KS-00000IZD; BDBM22816

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2732752
CAS Number: CAS 169037-23-4
TTD Drug ID: DMK3TEV

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Liver carboxylesterase (CES1)	TTMF541	EST1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Liver carboxylesterase (CES1)	DTT	CES1	12.04	6.525	5.311	5.909

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Liver carboxylesterase (CES1)	DTT	CES1	3.82E-08	1.86	1.9

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85.