Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMK4XT8)

Drug Name
SR 144190 Drug Info
Synonyms SR-144190; 3-(1-(2-(4-benzoyl-2-(3,4-difluorophenyl)morpholin-2-yl)ethyl)-4-phenylpiperidin-4-yl)-1-dimethylurea
Indication
Disease Entry ICD 11 Status REF
Acute or chronic pain MG30-MG31 Discontinued in Phase 1 [1]
Anxiety disorder 6B00-6B0Z Discontinued in Phase 1 [1]
Depression 6A70-6A7Z Discontinued in Phase 1 [1]
Urinary incontinence MF50.2 Discontinued in Phase 1 [1]
Therapeutic Class
Analgesics
Cross-matching ID
PubChem CID
9810217
TTD Drug ID
DMK4XT8

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Substance-K receptor (TACR2) TTYO0A3 NK2R_HUMAN Antagonist [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Substance-K receptor (TACR2) DTT TACR2 2.807 7.373 5.433 6.018
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Acute or chronic pain
ICD Disease Classification MG30-MG31
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Substance-K receptor (TACR2) DTT TACR2 6.83E-01 -2.22E-03 -0.01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008589)
2 Pharmacologic evaluation of neurokinin-2 receptor antagonists in the guinea pig respiratory tract. Am J Vet Res. 2004 Jul;65(7):984-91.