Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMK7XYH)

Drug Name
PF-07284890 Drug Info
Synonyms
Tinlorafenib; ARRY-461; Tinlorafenib [USAN]; PF-07284890; JNJ5N2RH5W; AR00504461; UNII-JNJ5N2RH5W; 2573781-75-4; WHO 12353; 1-Propanesulfonamide, N-(2-chloro-3-((3,4-dihydro-3,5-dimethyl-4-oxo-6-quinazolinyl)amino)-4-fluorophenyl)-3-fluoro-; N-(2-chloro-3-((3,5-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)-4-fluorophenyl)-3-fluoropropane-1-sulfonamide; tinlorafenib [INN]; ARRY461; CHEMBL5095256; SCHEMBL22831935; GTPL12096; BDBM565133; EX-A7593; HY-147405; CS-0564141; PF07284890; PF-07284890; ARRY-461; US11414404, Ex. # 10
Indication
Disease Entry ICD 11 Status REF
Melanoma 2C30 Phase 1 [1]
Cross-matching ID
PubChem CID
155434855
TTD Drug ID
DMK7XYH

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Serine/threonine-protein kinase B-raf (BRAF) TTWCGQT BRAF_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Serine/threonine-protein kinase B-raf (BRAF) DTT BRAF 6.409 7.097 6.062 6.049
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Melanoma
ICD Disease Classification 2C30
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Serine/threonine-protein kinase B-raf (BRAF) DTT BRAF 3.00E-01 0.1 0.2
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT04543188) A TWO-PART, PHASE 1A/B, OPEN-LABEL, MULTICENTER TRIAL EVALUATING PHARMACOKINETICS, SAFETY AND EFFICACY OF PF-07284890 (ARRY 461) IN PARTICIPANTS WITH BRAF V600 MUTANT SOLID TUMORS WITH AND WITHOUT BRAIN INVOLVEMENT. U.S.National Institutes of Health.
2 Clinical pipeline report, company report or official report of Pfzer