Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMK8V7A)

Drug Name
Imidazo[1,2-b]pyridazine derivative 5 Drug Info
Synonyms PMID28270010-Compound-Figure8-2
Cross-matching ID
TTD Drug ID
DMK8V7A

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tropomyosin-related kinase A (TrkA) TTTDVOJ NTRK1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Tropomyosin-related kinase A (TrkA) DTT NTRK1 0.848 1.138 2.293 2.722
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tropomyosin-related kinase A (TrkA) DTT NTRK1 8.72E-01 -0.04 -0.22
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751.