Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMK9743)

Drug Name

Trimetoquinol Drug Info

Synonyms

Trimetoquinol; Trimethoquinol; Inolin; Trimetoquinol-hydrochloride; AQL 208; Trikvinol (triquinol) hydrochloride; l-Trimetoquinol; Trimetoquinol (VAN); Trimethoquinol (VAN); AQ-110; CCRIS 1913; Tretoquinol l-form hydrochloride; Tetroquinol; EINECS 242-423-5; NSC 288748; TRETOQUINOL HYDROCHLORIDE; (-)-Trimethoquinol; AC1L1GTS; C19H23NO5.HCl; CHEMBL542101; SCHEMBL1630263; L-1-(3,4,5-Trimethylbenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline; AQL-208; 1-(3,4,5-Trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydroch

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 29137
CAS Number: CAS 18559-63-2
TTD Drug ID: DMK9743

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor beta-3 (ADRB3)	TTMXGCW	ADRB3_HUMAN	Agonist	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adrenergic receptor beta-3 (ADRB3)	DTT	ADRB3	2.392	2.655	2.278	1.982

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor beta-3 (ADRB3)	DTT	ADRB3	7.81E-01	0.02	0.16

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis and human beta-adrenoceptor activity of 1-(3,5-diiodo-4- methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-6-ol derivatives in vitro. J Med Chem. 2000 Feb 24;43(4):591-8.