Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMKCBIL)

Drug Name

6-chloro-1H-indazole Drug Info

Synonyms

6-Chloro-1H-indazole; 698-25-9; 6-Chloroindazole; 1H-Indazole, 6-chloro-; 1H-INDAZOLE,6-CHLORO-; CHEMBL392184; VUZQHUVRBPILAX-UHFFFAOYSA-N; AK-27924; 6-chloroazaindole; 6-chloro-indazole; NSC92743; PubChem20592; AC1L9DR4; SCHEMBL3533806; SCHEMBL16523332; CTK2F6854; DTXSID70329119; MolPort-000-002-984; HMS1629J03; 6-Chloro-1H-indazole, AldrichCPR; ACT06345; ZINC4878475; BCP00929; EBD48419; NSC-92743; BDBM50209236; BBL101057; STL554851; ANW-50721; FCH835101; AKOS005256021; AKOS024124978; RP01765; CS-W005017; VI20061; FS-2891; QC-2958; PB34228

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 417524
CAS Number: CAS 698-25-9
TTD Drug ID: DMKCBIL

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nitric-oxide synthase brain (NOS1)	TTZUFI5	NOS1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Nitric-oxide synthase brain (NOS1)	DTT	NOS1	6.085	5.844	5.849	5.806

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Nitric-oxide synthase brain (NOS1)	DTT	NOS1	5.20E-01	0.02	0.07

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3177-80.