Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMKEX7O)

Drug Name
Plecanatide Drug Info
Synonyms Trulance
Indication
Disease Entry ICD 11 Status REF
Chronic idiopathic constipation DC32 Approved [1]
Irritable bowel syndrome DD91.0 Approved [2]
Crohn disease DD70 Phase 3 [3]
Cross-matching ID
PubChem CID
70693500
CAS Number
CAS 467426-54-6
TTD Drug ID
DMKEX7O
ACDINA Drug ID
D00539

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Guanylyl cyclase C (GUCY2C) TTLDPRG GUC2C_HUMAN Modulator [4]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Guanylyl cyclase C (GUCY2C) DTT GUCY2C 4.542 7.698 3.797 7.565
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 13 Disease of the digestive system
Disease Class ICD-11: DD91 Irritable bowel syndrome
The Studied Tissue Rectal colon tissue
The Studied Disease Irritable bowel syndrome [ICD-11:DD91.0]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Guanylyl cyclase C (GUCY2C) DTT GUCY2C 2.18E-02 -0.31 -0.55
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2018
2 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
3 The druggable genome: Evaluation of drug targets in clinical trials suggests major shifts in molecular class and indication. Annu Rev Pharmacol Toxicol. 2014;54:9-26.
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.