Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMKFUO0)

Drug Name

6-Fluoromelatonin Drug Info

Synonyms

6-Fluoromelatonin; 62106-00-7; CHEMBL333886; N-(2-(6-Fluoro-5-methoxy-1H-indol-3-yl)ethyl)acetamide; N-[2-(6-fluoro-5-methoxy-1H-indol-3-yl)ethyl]acetamide; ACETAMIDE, N-(2-(6-FLUORO-5-METHOXY-1H-INDOL-3-YL)ETHYL)-; AC1L2ASC; SCHEMBL1772618; SCHEMBL1772619; DTXSID10211165; BTTITVUHHXXLFM-UHFFFAOYSA-N; ZINC2032560; BDBM50330858; LS-9627; N-[2-(5-methoxy-6-fluoroindol-3-yl)ethyl]acetamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 43922
CAS Number: CAS 62106-00-7
TTD Drug ID: DMKFUO0

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 2B receptor (HTR2B)	TT0K1SC	5HT2B_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 2B receptor (HTR2B)	DTT	HTR2B	0.485	3.536	0.379	4.667

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 2B receptor (HTR2B)	DTT	HTR2B	2.08E-01	-0.05	-0.23

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify no... J Med Chem. 2010 Nov 11;53(21):7573-86.