Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMKT2MB)

Drug Name

1-(4-nitrobenzyl)-1H-imidazole Drug Info

Synonyms

1-(4-Nitrobenzyl)-1H-imidazole; 18994-90-6; 1-(4-Nitrobenzyl)imidazole; 1-[(4-nitrophenyl)methyl]imidazole; Imidazole, 1-(4-nitrobenzyl)-; CHEMBL13784; 1H-Imidazole, 1-[(4-nitrophenyl)methyl]-; FLYGQJXMRPZYHQ-UHFFFAOYSA-N; 1-(4-Nitro-benzyl)-1H-imidazole; [(4-nitrophenyl)methyl]imidazole; AC1LBNLW; AC1Q1ZC3; ACMC-1C81T; SCHEMBL78081; CTK4E0266; DTXSID10342908; MolPort-001-494-965; KS-000024IG; ZINC1027711; ALBB-024046; CN-460; ANW-23472; STK149522; SBB093104; BDBM50188093; 1-(4-Nitrobenzyl)-1H-imidazole #; AKOS003266265; VI10027

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 585819
CAS Number: CAS 18994-90-6
TTD Drug ID: DMKT2MB

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Steroid 17-alpha-monooxygenase (S17AH)	TTRA5BZ	CP17A_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Steroid 17-alpha-monooxygenase (S17AH)	DTT	CYP17A1	6.213	5.615	6.895	6.025

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Steroid 17-alpha-monooxygenase (S17AH)	DTT	CYP17A1	6.87E-01	0.07	0.21

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hy... Bioorg Med Chem Lett. 2006 Aug 1;16(15):4011-5.