Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DML2B04)

Drug Name

DIOXINODEHYDROECKOL Drug Info

Synonyms

DIOXINODEHYDROECKOL; Eckstolonol; UNII-N5P71K0GE3; CHEMBL559870; N5P71K0GE3; CHEBI:65820; 5,8,13,14-tetraoxa-pentaphene-1,3,6,9,11-pentol; [1,4]benzodioxino[2,3-a]oxanthrene-1,3,6,9,11-pentol; SCHEMBL14848420; BDBM50319629; 5,8,13,14-Tetraoxa-pentaphene-1,3,6,9,11-pentaol; Benzo(1,2-b:3,4-b')bis(1,4)benzodioxin-1,3,6,9,11-pentol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10429214
ChEBI ID: CHEBI:65820
CAS Number: CAS 639514-05-9
TTD Drug ID: DML2B04

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Beta-secretase (BACE)	TT8JRS7	NOUNIPROTAC	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Beta-secretase (BACE)	DTT	BACE	5.928	4.638	6.443	5.3

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Beta-secretase (BACE)	DTT	NO-GeName	6.98E-04	1.03	2.84

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3211-5.