Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DML2ZWR)

Drug Name

Solubilized type 1 native bovine collagen Drug Info

Synonyms

Solubilized type 1 native bovine collagen (oral, scleroderma); Solubilized type 1 native bovine collagen (oral, scleroderma), arGentis/University of Tennessee

Indication

Disease Entry	ICD 11	Status	REF
Scleroderma	4A42	Phase 2	[1]

Cross-matching ID

TTD Drug ID: DML2ZWR

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Collagen I (COL1A2)	TTUABC1	CO1A2_HUMAN	Modulator	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Collagen I (COL1A2)	DTT	COL1A2	5.421	9.056	8.45	8.38

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Scleroderma

ICD Disease Classification

4A42

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Collagen I (COL1A2)	DTT	COL1A2	1.49E-09	4.86	4

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026882)
2	Company report (Argentisrx)