Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DML906E)

Drug Name
CY-1503 Drug Info
Synonyms Cylexin
Indication
Disease Entry ICD 11 Status REF
Hypertension BA00-BA04 Phase 2/3 [1]
Cross-matching ID
TTD Drug ID
DML906E

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
E-selectin (SELE) TTAU4D6 LYAM2_HUMAN Modulator [2]
P-selectin (SELP) TTE5VG0 LYAM3_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
P-selectin (SELP) DTT SELP 7.304 7.427 7.315 7.849
E-selectin (SELE) DTT SELE 5.194 3.307 3.104 5.907
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Hypertension
ICD Disease Classification BA00-BA04
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
E-selectin (SELE) DTT SELE 6.43E-04 0.02 0.12
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT00226369) Cylexin for Reduction of Reperfusion Injury in Infant Heart Surgery. U.S. National Institutes of Health.
2 Adjunctive selectin blockade successfully reduces infarct size beyond thrombolysis in the electrolytic canine coronary artery model. Circulation. 1995 Aug 1;92(3):492-9.