General Information of Drug (ID: DMLAH39)

Drug Name
PMID25435179-Compound-WO2012106509Salermide Drug Info
Cross-matching ID
TTD Drug ID
DMLAH39

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
NAD-dependent deacetylase sirtuin-1 (SIRT1) TTUF2HO SIR1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
NAD-dependent deacetylase sirtuin-1 (SIRT1) DTT SIRT1 6.202 6.863 6.331 6.61
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
NAD-dependent deacetylase sirtuin-1 (SIRT1) DTT SIRT1 7.25E-01 -0.06 -0.16
NAD-dependent deacetylase sirtuin-1 (SIRT1) DTT SIRT1 2.92E-05 -0.25 -0.64
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Sirtuin modulators: an updated patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):5-15.