Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMLGK27)

Drug Name
LA-N8 Drug Info
Synonyms GlycoPEG-FVIII; Long-acting recombinant FVIIII (N8), Novo Nordisk; Factor VIII (recombinant/GlycoPEGylated, hemophilia A), Novo Nordisk/Neose
Indication
Disease Entry ICD 11 Status REF
Factor VIII deficiency 3B10 Investigative [1]
Cross-matching ID
TTD Drug ID
DMLGK27

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Coagulation factor VIII (F8) TT1290U FA8_HUMAN Modulator [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Coagulation factor VIII (F8) DTT F8 7.637 6.9 7.644 6.975
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Factor VIII deficiency
ICD Disease Classification 3B10
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Coagulation factor VIII (F8) DTT F8 1.08E-22 0.89 1.82
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2607).