Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMLI5VH)

Drug Name

MDL 100,453 Drug Info

Synonyms

D-Norvaline, 4-oxo-5-phosphono-; CHEMBL431029; MDL-100483; 129938-34-7; 4-Opnv; Mdl 100453; 4-Oxo-5-phosphononorvaline; AC1MHZND; SCHEMBL195547; (r)-4-oxo-5-phosphononorvaline; BDBM50010893; AKOS030593176; MDL-100453; 2-Amino-4-oxo-5-phosphono-pentanoic acid; (2R)-2-amino-4-oxo-5-phosphonopentanoic acid; (R)-2-Amino-4-oxo-5-phosphono-pentanoic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3035602
CAS Number: CAS 129938-34-7
TTD Drug ID: DMLI5VH

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor ionotropic NMDA 2A (NMDAR2A)	TTKJEMQ	NMDE1_HUMAN	Antagonist	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Glutamate receptor ionotropic NMDA 2A (NMDAR2A)	DTT	GRIN2A	5	5.446	5.459	3.35

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glutamate receptor ionotropic NMDA 2A (NMDAR2A)	DTT	GRIN2A	8.43E-01	-0.37	-0.45

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Differing effects of N-methyl-D-aspartate receptor subtype selective antagonists on dyskinesias in levodopa-treated 1-methyl-4-phenyl-tetrahydropyridine monkeys. J Pharmacol Exp Ther. 1999 Sep;290(3):1034-40.