Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMLKI2B)

• Drug Name: Trafermin Drug Info
• Synonyms: Fiblast; Fiblast (TN); Trafermin (genetical recombination); Trafermin (USAN/INN); Trafermin (genetical recombination) (JAN)

Indication

Disease Entry	ICD 11	Status	REF
Periodontitis	DA0C	Phase 3	[1]

• Cross-matching ID: TTD Drug ID: DMLKI2B

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fibroblast growth factor receptor 2 (FGFR2)	TTGJVQM	FGFR2_HUMAN	Activator	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Fibroblast growth factor receptor 2 (FGFR2)	DTT	FGFR2	3.485	4.142	4.8	3.062

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Periodontitis
• ICD Disease Classification: DA0C

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Fibroblast growth factor receptor 2 (FGFR2)	DTT	FGFR2	4.82E-01	-0.03	-0.2

References

• [1] Emerging drugs for diabetic foot ulcers. Expert Opin Emerg Drugs. 2006 Nov;11(4):709-24.