Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMLN4V5)

Drug Name

EPZ-004777 Drug Info

Synonyms

DOT1L inhibitors (mixed lineage leukemia); DOT1L inhibitors (leukemia), Epizyme/GSK; DOT1L inhibitors (mixed lineage leukemia), Epizyme/GlaxoSmithKline

Indication

Disease Entry	ICD 11	Status	REF
leukaemia	2A60-2B33	Investigative	[1]

Cross-matching ID

PubChem CID: 56962336
ChEBI ID: CHEBI:124920
CAS Number: CAS 1338466-77-5
TTD Drug ID: DMLN4V5

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histone-lysine N-methyltransferase (HLNM)	TTSZ8T1	DOT1L_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Histone-lysine N-methyltransferase (HLNM)	DTT	DOT1L	2.406	1.585	1.848	2.138

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

leukaemia

ICD Disease Classification

2A60-2B33

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Histone-lysine N-methyltransferase (HLNM)	DTT	DOT1L	7.62E-02	0.08	0.2

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7377).
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7377).