Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMM1RCS)

• Drug Name: 4-(piperazin-1-yl)-1H-indole Drug Info
• Synonyms: 4-(1-Piperazinyl)-1H-indole; 84807-09-0; 4-(piperazin-1-yl)-1H-indole; 4-Piperazino-1H-indole; 1H-Indole, 4-(1-piperazinyl)-; 4-(Piperazino)indole; 4-piperazin-1-yl-1H-indole; 1-(4-indolyl)piperazine; CHEMBL200234; YZKSXUIOKWQABW-UHFFFAOYSA-N; AK-26360; W-206959; 1H-Indole-4-(1-piperazinyl)dihydrochloride; 4-piperazinoindole; 4-piperazino-indole; PubChem22668; AC1LC5AN; 1H-indol-4-ylpiperazine; 4-(1-piperazinyl)indole; 1-(indol-4yl)piperazine; 1-(indol-4yl)-piperazine; 1-(indol-4-yl)piperazine; 1-(4-indolyl)-piperazine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 594590
  CAS Number: CAS 84807-09-0
  TTD Drug ID: DMM1RCS

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 6 receptor (HTR6)	TTJS8PY	5HT6R_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 6 receptor (HTR6)	DTT	HTR6	5.594	5.781	5.271	3.963

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 6 receptor (HTR6)	DTT	HTR6	1.23E-05	-0.12	-0.71

References

• [1] Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5298-302.