Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMM4FXA)

Drug Name

Asfotase alfa Drug Info

Synonyms

SPHEX, BioMep; SPHEX, Enobia; PHEX-based enzyme replacement therapy, BioMep; PHEX-based enzyme replacement therapy, Enobia; X-linked hypophosphatemic rickets therapy, BioMep; X-linked hypophosphatemic rickets therapy, Enobia

Indication

Disease Entry	ICD 11	Status	REF
Genetic disease	8E02	Approved	[1]

Cross-matching ID

TTD Drug ID: DMM4FXA

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Alkaline phosphatase tissue-nonspecific (ALPL)	TTMR5UV	PPBT_HUMAN	Modulator	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Alkaline phosphatase tissue-nonspecific (ALPL)	DTT	ALPL	6.35	4.07	5.7	3.609

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Genetic disease

ICD Disease Classification

8E02

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Alkaline phosphatase tissue-nonspecific (ALPL)	DTT	ALPL	4.67E-13	-0.15	-0.79

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	ClinicalTrials.gov (NCT01176266) Open-Label Study of Asfotase Alfa in Infants and Children 5 Years of Age With Hypophosphatasia (HPP). U.S. National Institutes of Health.
2	Enzyme-replacement therapy in life-threatening hypophosphatasia. N Engl J Med. 2012 Mar 8;366(10):904-13.