Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMMD9A0)

Drug Name
N,N-dimethyl-2-(pyridin-3-yloxy)ethanamine Drug Info
Synonyms
CHEMBL61616; 228272-02-4; N,N-dimethyl-2-(pyridin-3-yloxy)ethanamine; SCHEMBL12827198; CTK0J6066; DTXSID40436622; BDBM50115808; AKOS030595283; Dimethyl 2-(3-pyridinyloxy)ethylamine; Dimethyl-[2-(pyridin-3-yloxy)-ethyl]-amine; N,N-dimethyl-2-(pyridin-3-yloxy)ethanaminium; Ethanamine, N,N-dimethyl-2-(3-pyridinyloxy)-
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10197862
CAS Number
CAS 228272-02-4
TTD Drug ID
DMMD9A0

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Neuronal acetylcholine receptor alpha-4 (CHRNA4) TT4H1MQ ACHA4_HUMAN Inhibitor [1]
Neuronal acetylcholine receptor beta-2 (CHRNB2) TT5KPZR ACHB2_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Neuronal acetylcholine receptor beta-2 (CHRNB2) DTT CHRNB2 4.678 3.907 5.096 5.87
Neuronal acetylcholine receptor alpha-4 (CHRNA4) DTT CHRNA4 4.409 3.585 4.385 4.591
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Neuronal acetylcholine receptor beta-2 (CHRNB2) DTT CHRNB2 7.10E-08 -0.15 -0.85
Neuronal acetylcholine receptor alpha-4 (CHRNA4) DTT CHRNA4 3.51E-10 -0.15 -0.61
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2013-6.