Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMMDZ4B)

Drug Name

LAU-0901 Drug Info

Synonyms

PAF receptor antagonist (brain ischemia/ corneal disease), Louisiana State University; Platelet-activating factor receptor antagonist (brain ischemia/ corneal disease), Louisiana State University

Indication

Disease Entry	ICD 11	Status	REF
Brain ischaemia	8B1Z	Investigative	[1]

Cross-matching ID

PubChem CID: 9830370
TTD Drug ID: DMMDZ4B

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Platelet-activating factor receptor (PTAFR)	TTQL5VC	PTAFR_HUMAN	Antagonist	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Platelet-activating factor receptor (PTAFR)	DTT	PTAFR	6.345	5.947	6.084	6.253

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Brain ischaemia

ICD Disease Classification

8B1Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Platelet-activating factor receptor (PTAFR)	DTT	PTAFR	3.53E-02	0.33	2.12

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Superior Neuroprotective Efficacy of LAU-0901, a Novel Platelet-Activating Factor Antagonist, in Experimental Stroke. Transl Stroke Res. 2012 Mar;3(1):154-63.