Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMMETU8)

Drug Name
PF-4418948 Drug Info
Synonyms PF-04418948; Prostaglandin E2 EP2 subtype antagonist (endometriosis), Pfizer
Indication
Disease Entry ICD 11 Status REF
Endometriosis GA10 Phase 1 [1]
Cross-matching ID
PubChem CID
25114442
CAS Number
CAS 1078166-57-0
TTD Drug ID
DMMETU8

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prostaglandin E2 receptor EP2 (PTGER2) TT1ZAVI PE2R2_HUMAN Antagonist [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Prostaglandin E2 receptor EP2 (PTGER2) DTT PTGER2 4.75 5.888 5.066 4.466
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 16 Disease of the genitourinary system
Disease Class ICD-11: GA10 Endometriosis
The Studied Tissue Endometrium tissue
The Studied Disease Endometriosis [ICD-11:GA10]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Prostaglandin E2 receptor EP2 (PTGER2) DTT PTGER2 2.77E-06 1.15 1.37
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5817).
2 Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Expert Opin Ther Pat. 2015 Jul;25(7):837-44.