Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMMGAUK)

• Drug Name: AGN-XX/YY Drug Info
• Synonyms: Rezatomidine

Indication

Disease Entry	ICD 11	Status	REF
Diabetic nephropathy	GB61.Z	Phase 2	[1]
Fibromyalgia	MG30.01	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 11287722
  CAS Number: CAS 847829-38-3
  TTD Drug ID: DMMGAUK

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-2C (ADRA2C)	TT2NUT5	ADA2C_HUMAN	Agonist	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	5.013	2.379	5.594	2.07

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Diabetic nephropathy
• ICD Disease Classification: GB61.Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	1.76E-01	-0.06	-0.28

References

• [1] Clinical pipeline report, company report or official report of ACADIA Pharmaceuticals.
• [2] Patent WO2008058220 A2.