General Information of Drug (ID: DMMNIRC)

Drug Name
N-methyl-4-(pyridin-3-yl)but-3-yn-1-amine Drug Info
Synonyms
CHEMBL54860; N-methyl-4-(pyridin-3-yl)but-3-yn-1-amine; SCHEMBL3023293; WBAIXNUCEGCLDC-UHFFFAOYSA-N; BDBM50138489; Methyl-(4-pyridin-3-yl-but-3-ynyl)-amine; N-Methyl-4-(3pyridinyl)-3-butyne-1-amine; 1-(3-Pyridinyl)-4-(methylamino)-1-butyne; N-Methyl-4-(3-pyridinyl)-3-butyne-1-amine
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
15860335
TTD Drug ID
DMMNIRC

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Neuronal acetylcholine receptor alpha-4 (CHRNA4) TT4H1MQ ACHA4_HUMAN Inhibitor [1]
Neuronal acetylcholine receptor beta-2 (CHRNB2) TT5KPZR ACHB2_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Neuronal acetylcholine receptor beta-2 (CHRNB2) DTT CHRNB2 4.678 3.907 5.096 5.87
Neuronal acetylcholine receptor alpha-4 (CHRNA4) DTT CHRNA4 4.409 3.585 4.385 4.591
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Neuronal acetylcholine receptor beta-2 (CHRNB2) DTT CHRNB2 7.10E-08 -0.15 -0.85
Neuronal acetylcholine receptor alpha-4 (CHRNA4) DTT CHRNA4 3.51E-10 -0.15 -0.61
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2013-6.