General Information of Drug (ID: DMMP7XG)

Drug Name
MAXY-4 Drug Info
Synonyms CTLA4-Ig proteins (rheumatoid arthritis), Maxygen
Indication
Disease Entry ICD 11 Status REF
Autoimmune diabetes 5A10 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMMP7XG

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Activation B7-1 antigen (CD80) TTFZDNP CD80_HUMAN Inhibitor [2]
T-lymphocyte activation antigen CD86 (FUN1) TTHGXBU CD86_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
T-lymphocyte activation antigen CD86 (FUN1) DTT CD86 3.818 5.594 4.466 5.426
Activation B7-1 antigen (CD80) DTT CD80 6.576 6.711 6.951 6.944
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Autoimmune diabetes
ICD Disease Classification 5A10
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Activation B7-1 antigen (CD80) DTT CD80 6.87E-07 -0.12 -0.3
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT02052375) A Study To Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of ASP2408 After Multiple Dose Subcutaneous Injections in Patients With RheumatoidArthritis on Methotrexate. U.S. National Institutes of Health.
2 Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science. 2011 Apr 29;332(6029):600-3.