Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMMUYC2)

• Drug Name: YM-344031 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Asthma	CA23	Preclinical	[1]

• Cross-matching ID:
  PubChem CID: 56603737
  TTD Drug ID: DMMUYC2

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C-C chemokine receptor type 3 (CCR3)	TTD3XFU	CCR3_HUMAN	Antagonist	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
C-C chemokine receptor type 3 (CCR3)	DTT	CCR3	3.982	4.271	3.838	3.609

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• ICD Disease Classification: 12 Disease of the respiratory system
• Disease Class: ICD-11: CA23 Asthma
• The Studied Tissue: Nasal and bronchial airway
• The Studied Disease: Asthma [ICD-11:CA23]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
C-C chemokine receptor type 3 (CCR3)	DTT	CCR3	2.97E-06	-0.44	-0.48

References

• [1] Emerging drugs for asthma. Expert Opin Emerg Drugs. 2008 Dec;13(4):643-53.