Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMN1XVC)

• Drug Name: Lutetium Lu 177 dotatate Drug Info
• Synonyms: UNII-AE221IM3BB; Dotatate lutenium Lu-177; AE221IM3BB; Lu-DOTA-TATE; 177Lu-DOTA-octreotate; Lutetium Lu 177 Dotatate; 177Lu-DOTA-Tyr3-octreotate

Indication

Disease Entry	ICD 11	Status	REF
Neuroendocrine cancer	2B72.1	Approved	[1]

• Cross-matching ID:
  PubChem CID: 132274234
  CAS Number: CAS 437608-50-9
  TTD Drug ID: DMN1XVC

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Somatostatin receptor type 1 (SSTR1)	TTIND6G	SSR1_HUMAN	Antagonist	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Somatostatin receptor type 1 (SSTR1)	DTT	SSTR1	5.588	3.392	4.087	4.009

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Neuroendocrine cancer
• ICD Disease Classification: 2B72.1

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Somatostatin receptor type 1 (SSTR1)	DTT	SSTR1	2.39E-14	-0.6	-0.83

References

• [1] 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.