Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMN2EI1)

Drug Name
bis-triazole derivative 10 Drug Info
Synonyms CHEMBL2016873; bis-triazole derivative 10; GTPL6537; SCHEMBL15308834
Indication
Disease Entry ICD 11 Status REF
Otitis media AA80-AB0Z Clinical trial [1]
Cross-matching ID
PubChem CID
56599309
TTD Drug ID
DMN2EI1

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Plasminogen (PLG) TTP86E2 PLMN_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Plasminogen (PLG) DTT PLG 11.754 0.848 8.393 2.138
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Otitis media
ICD Disease Classification AA80-AB0Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Plasminogen (PLG) DTT PLG 8.61E-01 -0.01 -0.09
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6537).
2 A new strategy for the development of highly potent and selective plasmin inhibitors. J Med Chem. 2012 Feb 9;55(3):1171-80.