Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMN32UV)

Drug Name
RZ358 Drug Info
Indication
Disease Entry ICD 11 Status REF
Congenital hyperinsulinism 5A4Y Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMN32UV

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Insulin receptor (INSR) TTCBFJO INSR_HUMAN Not Available [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Insulin receptor (INSR) DTT INSR 5.213 5.838 5.779 5.591
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Congenital hyperinsulinism
ICD Disease Classification 5A4Y
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Insulin receptor (INSR) DTT INSR 1.03E-05 0.26 0.66
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT04538989) An Open-Label Multiple-Dose Study of RZ358 in Patients With Congenital Hyperinsulinism. U.S.National Institutes of Health.
2 Clinical pipeline report, company report or official report of Rezolute