Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMN4SE5)

Drug Name
Pyrrolo-pyrrolone derivative 1 Drug Info
Synonyms PMID26924192-Compound-34
Cross-matching ID
PubChem CID
122553486
TTD Drug ID
DMN4SE5

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bromodomain-containing protein 2 (BRD2) TTDP48B BRD2_HUMAN Inhibitor [1]
Bromodomain-containing protein 3 (BRD3) TTHE657 BRD3_HUMAN Inhibitor [1]
Bromodomain-containing protein 4 (BRD4) TTRA6BO BRD4_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Bromodomain-containing protein 4 (BRD4) DTT BRD4 6.686 6.622 6.963 6.725
Bromodomain-containing protein 3 (BRD3) DTT BRD3 7.247 7.37 6.934 7.459
Bromodomain-containing protein 2 (BRD2) DTT BRD2 7.097 7.05 7.028 7.65
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Bromodomain-containing protein 4 (BRD4) DTT BRD4 3.27E-01 0.02 0.04
Bromodomain-containing protein 3 (BRD3) DTT BRD3 8.51E-01 -0.03 -0.13
Bromodomain-containing protein 2 (BRD2) DTT BRD2 6.53E-02 -0.05 -0.13
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22.