Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMNCOE1)

• Drug Name: FRM-6308 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Schizophrenia	6A20	Phase 1b	[1]

• Cross-matching ID: TTD Drug ID: DMNCOE1

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphodiesterase 10A (PDE10)	TTJW4LU	PDE10_HUMAN	Inhibitor	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Phosphodiesterase 10A (PDE10)	DTT	PDE10A	5.313	4.436	5.65	5.516

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• ICD Disease Classification: 06 Mental, behavioural or neurodevelopmental disorder
• Disease Class: ICD-11: 6A20 Schizophrenia
• The Studied Tissue: Pre-frontal cortex
• The Studied Disease: Schizophrenia [ICD-11:6A20]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Phosphodiesterase 10A (PDE10)	DTT	PDE10A	1.99E-01	-0.07	-0.21
Phosphodiesterase 10A (PDE10)	DTT	PDE10A	4.51E-01	-0.05	-0.32

References

• [1] Clinical pipeline report, company report or official report of Forum pharmaceuticals.
• [2] Massive schizophrenia genomics study offers new drug directions. Nat Rev Drug Discov. 2014 Sep;13(9):641-2.