Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMNET19)

Drug Name
Pyrimidine derivative 5 Drug Info
Synonyms PMID28621580-Compound-US20160096832c60
Indication
Disease Entry ICD 11 Status REF
Blood vessel proliferative disorder BE2Z Patented [1]
Fibrosis GA14-GC01 Patented [1]
Neurodegenerative disorder 8A20-8A23 Patented [2]
Cross-matching ID
TTD Drug ID
DMNET19

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Vascular endothelial growth factor A (VEGFA) TTOHSBA VEGFA_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Vascular endothelial growth factor A (VEGFA) DTT VEGFA 8.544 6.927 7.253 7.839
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Blood vessel proliferative disorder
ICD Disease Classification BE2Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Vascular endothelial growth factor A (VEGFA) DTT VEGFA 3.61E-01 0.15 0.47
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004.
2 Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34.