Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMNF38S)

Drug Name
16,16-dimethyl-PGE2 Drug Info
Synonyms 16,16-dimethylprostaglandin E2
Indication
Disease Entry ICD 11 Status REF
Stem cell engraftment QB63.8 Phase 2 [1]
Cross-matching ID
PubChem CID
5283066
ChEBI ID
CHEBI:141046
CAS Number
CAS 39746-25-3
TTD Drug ID
DMNF38S

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prostaglandin E2 receptor EP2 (PTGER2) TT1ZAVI PE2R2_HUMAN Agonist [2]
Prostaglandin E2 receptor EP3 (PTGER3) TTPNGDE PE2R3_HUMAN Agonist [2]
Prostaglandin E2 receptor EP4 (PTGER4) TT79WV3 PE2R4_HUMAN Agonist [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Prostaglandin E2 receptor EP3 (PTGER3) DTT PTGER3 4.768 4.711 6.12 3.579
Prostaglandin E2 receptor EP4 (PTGER4) DTT PTGER4 4.907 7.298 6.097 7.251
Prostaglandin E2 receptor EP2 (PTGER2) DTT PTGER2 4.75 5.888 5.066 4.466
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Stem cell engraftment
ICD Disease Classification QB63.8
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Prostaglandin E2 receptor EP2 (PTGER2) DTT PTGER2 2.77E-06 1.15 1.37
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24.