General Information of Drug (ID: DMNO46U)

Drug Name
N-(4-Chloro-7-p-tolyl-isoquinolin-1-yl)-guanidine Drug Info
Synonyms CHEMBL109274; N-(4-Chloro-7-p-tolyl-isoquinolin-1-yl)-guanidine
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
44339119
TTD Drug ID
DMNO46U

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Plasminogen (PLG) TTP86E2 PLMN_HUMAN Inhibitor [1]
Tissue-type plasminogen activator (PLAT) TTXAGYU TPA_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Plasminogen (PLG) DTT PLG 11.754 0.848 8.393 2.138
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Plasminogen (PLG) DTT PLG 8.61E-01 -0.01 -0.09
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-isoquinolinylguanidines. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3227-30.