Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMNRCDI)

Drug Name

7-Fluoro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one Drug Info

Synonyms

CHEMBL323071; 7-Fluoro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one; SCHEMBL10757077; 2H-Imidazo[4,5-b]quinolin-2-one, 7-fluoro-1,3-dihydro-; BDBM50007234

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 13936969
TTD Drug ID: DMNRCDI

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphodiesterase 3A (PDE3A)	TT06AWU	PDE3A_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Phosphodiesterase 3A (PDE3A)	DTT	PDE3A	4.717	6.087	5.051	5.051

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Phosphodiesterase 3A (PDE3A)	DTT	PDE3A	3.33E-01	1.35E-02	0.14

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation. J Med Chem. 1991 Sep;34(9):2906-16.